Percutaneous and surgical interventions on vessels often results in distal embolization of atherosclerotic debries downstream. This is usually silent, however, in saphenous vein interventions, carotid interventions, and possibly renal artery stenting distal embolisation may results in clinically significant events including myocardial infarction, stroke, and renal failure. Emboli protection devices trap blood and suspended debris in the body of the saphenous vein graft (occlusion balloons) or trap debris (baskets) during stenting, allowing their evacuation before unobstructed flow is restored. Studies with these devices have shown that large quantities of atheroembolic debris are liberated during intervention and Preliminary results of the SAFER trial show that use of the Percusurge device (balloon occlusion device), with or without the concomitant use of platelet IIb/IIIa receptor blockers, reduces the incidence of major adverse cardiac events by ~50 percent. Trials of other distal protection devices and filters in saphenous vein grafts, carotids, and renal arteries are currently underway.